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A recent study, comparing the maize SILKY1 gene to its well-characterized homolog APETALA3 from Arabidopsis, has provided some of the first evidence pointing to conservation of homeotic gene function between mono...
Using DNA microarrays, 381 genes have been found to be induced in response to unfolded proteins. The identity of the previously characterized 208 of these, and further experiments, have revealed new details on...
The budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe are as different from each other as either is from animals: their ancestors separated about 420 to 330 million years ago....
Several studies are starting to show the power of DNA microarrays to identify interactions between animal hosts and their pathogens, and have revealed interesting correlations between host responses to differe...
Large gene expression studies, such as those conducted using DNA arrays, often provide millions of different pieces of data. To address the problem of analyzing such data, we describe a statistical method, whi...
The recent completion of the DNA sequence of human chromosome 21 has provided the first look at the 225 genes that are candidates for involvement in Down syndrome (trisomy 21). A broad functional classificatio...
The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recomb...
Genomic approaches to the study of the expression of plant genes induced in response to disease and attack are now showing that there is an intimate association between pathogen perception and general stress d...
A comparison of drought tolerance in plants at extreme ends of the evolutionary spectrum is beginning to show the mechanisms involved.
A meeting report from the 13th Annual Cold Spring Harbor meeting on Genome Sequencing and Biology, May 10-14, 2000. Cold Spring Harbor, New York
A report from the conference entitled Genome Based Gene Structure Determination, Hinxton, UK, 1-2 June, 2000, organised by the European Bioinformatics Institute (EBI).
White spotting patterns in mammals can be caused by mutations in the genes for the endothelin B receptor and c-Kit, whose protein products are necessary for proper migration, differentiation or survival of the...
Webcutter provides a free and easy-to-use interface for the analysis of restriction sites in any sequence.
BoxShade takes sequence alignments and creates an output file in which the alignment is displayed with identical or similar residues shaded in two different tones of gray.
The chemotropic factor semaphorin 3A has been shown to act in both the axonal and dendritic guidance of cortical pyramidal neurons.
Early response genes encoding potential regulators of pathogen and wound-induced plant responses have been identified using gene expression profiling.
The existence of several distinct plant signaling pathways regulating changes in gene expression in response to wounding has been demonstrated using cDNA microarray analysis.
DNA libraries from uncultured soil-microbes have revealed insights into the functional and genomic diversity of soil bacteria.
The availability of the complete sequence of the vaccinia virus genome has enabled a comprehensive two-hybrid analysis in yeast of virus protein-protein interactions.
The complete DNA sequence of human chromosome 21 is now available.
A key enzyme involved in flavor biogenesis in ripening strawberries has been discovered using customized cDNA microarrays.
A new method for identifying biologically relevant sequences by their DNA structure has been described.
New phylogenetic analyses have suggested that a single primary endosymbiosis occurred at the origin of green plants, red algae and glaucophytes.
Expression of paternal alleles for 20 loci expressed during early seed development in Arabidopsis was undetectable during early embryo and endosperm development, suggesting the presence of imprinting of the pater...
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