Fig. 5

The 3,211,228 junctions found in at least 20 reads across samples are accumulated by their “discovery dates.” Here, discovery date of a junction is taken to be the earliest submission date to the BioSample database from among the samples in which the junction was found. 96.1% of the junctions were discovered before 1 January 2013, although only 34.7% of samples depicted in the figure had been submitted by then, and afterwards discovery levels off. Demanding higher levels of confidence (the red, green, and orange curves) gives rise to earlier asymptotes. Ranked from 1 to 5 are the dominant contributing projects from dates on which the most junctions are discovered. “Che” refers to a study of 41 Coriell cell lines by Cheung et al. [21], “Pic” refers to a study of 69 LCLs by Pickrell et al. [20], “UWE” refers to the University of Washington Human Reference Epigenome Mapping Project [17], “BM2” refers to Illumina Body Map 2.0 [6], and “ENC” refers to ENCODE [19]. “GEU” refers to GEUVADIS [37], whose 464 LCLs uncovered few junctions that had not already been discovered